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Adeona Pharmaceuticals, Inc. ("Adeona") (AMEX:AEN) is a development-stage, specialty pharmaceutical company that is developing orally active, proprietary, late-stage drug candidates for the treatment of autoimmune diseases and central nervous system diseases. We are focused on developing treatments for rheumatoid arthritis (RA), multiple sclerosis (MS), dry age-related macular degeneration (AMD) and fibromyalgia.

Current Product Pipeline:

Oral dnaJP1:

Oral dnaJP1 Timeline

Rheumatoid Arthritis

Oral dnaJP1 is a once-daily epitope specific immunotherapy for rheumatoid arthritis (RA) patients. Oral dnaJP1 is a heat shock protein (hsp)-derived peptide which was previously identified as a contributor of T cell mediated inflammation in RA Immune responses to hsp are often found at sites of inflammation and have an initially amplifying effect that needs to be downregulated to prevent tissue damage. The mechanisms for this regulation involve T cells with regulatory function that are specific for hsp-derived antigens.
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Trimesta:

Trimesta Timeline

Relapsing Remitting Multiple Sclerosis

We are developing Trimestaª as an oral, immunomodulatory and anti-inflammatory agent for the North American market. Estriol has been approved and marketed throughout Europe and Asia as a mild estrogenic agent for over 40 years for the treatment of post-menopausal hot flashes.
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Zinthionein:

Zinthionein Timeline

Dry AMD

We are developing Zinthionein™ (oral zincmonocysteine), an orally active compound for the treatment of dry age-related macular degeneration (AMD). Oral ZMC the activity of antioxidant enzymes catalase and glutathione peroxidase, and the antioxidant protein metallothionein in cultured retinal pigment epithelial cells more efficiently and potently than currently available zinc formulations. These complexes are the subject of a recently issued U.S. Patent covering its composition of matter and a patent application and various uses thereof. Zinthionein™ has completed an 80 patient phase II clinical trial for the treatment of Dry AMD.
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Effirma:

Oral ZMC Timeline

Fibromyalgia Syndrome

We are developing EFFIRMA (oral flupirtine), a novel, centrally-active, oral therapy for the treatment of fibromyalgia syndrome (FMS) and we plan to conduct a limited, controlled phase II proof-of-concept clinical trial in this indication. FMS is a common, centrally-mediated pain disorder characterized by chronic diffuse pain and other symptoms.
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Anti-CD4 802-2:

CD4 Inhibitors Timeline

Graft Vs. Host Disease

We are developing a series of rationally-designed, small molecule/peptidomimetic inhibitors of the T-cell CD4 co-receptor. The CD4 co-receptor is central to a number of autoimmune disorders such as MS. Our anti-CD4 molecules are designed to selectively block the dimerization and oligomerization of adjacent CD4 receptors via the D1 domains of such receptors.
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